256: Incidence of recurrent fetal aneuploidy
نویسندگان
چکیده
منابع مشابه
Screening for Fetal Aneuploidy
Aneuploidy is defined as having one or more extra or missing chromosomes, leading to an unbalanced chromosome number in a cell. Because each chromosome consists of hundreds of genes, the loss or gain of large chromosomal segments disrupts significant amounts of genetic material and often results in a nonviable pregnancy or offspring that may not survive after birth. In the case of a surviving n...
متن کاملAneuploidy. Part A: Incidence and Etiology
This book, which is Volume 7A in a series entitled "Progress and Topics in Cytogenetics," is a collection of papers exploring topics in aneuploidy ranging from higher plants and Drosophilia to humans. The book is divided into two major sections-one on the incidence and the other on the etiology of aneuploidy. The first half deals with the incidence of aneuploidy in humans, rodents, farm animals...
متن کاملHuman aneuploidy: incidence, origin, and etiology.
Chromosome abnormalities occur with astonishing frequency in humans, being present in an estimated 1030% of all fertilized eggs. Of the different classes of chromosome abnormality, aneuploidy (trisomy and monosomy) is by far the most common and, clinically, the most important. For example, over 25% of all miscarriages are monosomic or trisomic, making aneuploidy the leading known cause of pregn...
متن کاملDigital PCR for the molecular detection of fetal chromosomal aneuploidy.
Trisomy 21 is the most common reason that women opt for prenatal diagnosis. Conventional prenatal diagnostic methods involve the sampling of fetal materials by invasive procedures such as amniocentesis. Screening by ultrasonography and biochemical markers have been used to risk-stratify pregnant women before definitive invasive diagnostic procedures. However, these screening methods generally t...
متن کاملMicrofluidic digital PCR enables rapid prenatal diagnosis of fetal aneuploidy.
OBJECTIVE The purpose of this study was to demonstrate that digital polymerase chain reaction (PCR) enables rapid, allele independent molecular detection of fetal aneuploidy. STUDY DESIGN Twenty-four amniocentesis and 16 chorionic villus samples were used for microfluidic digital PCR analysis. Three thousand and sixty PCR reactions were performed for each of the target chromosomes (X, Y, 13, ...
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ژورنال
عنوان ژورنال: American Journal of Obstetrics and Gynecology
سال: 2017
ISSN: 0002-9378
DOI: 10.1016/j.ajog.2016.11.162